For The First Time, Scientists Create a 3D Map of Chromosomes’ Organization !

In collaboration with researchers from the Weizmann Institute in Israel, a team from the Institut de Génétique Humaine (CNRS) has, for the first time, revealed the detailed three-dimensional architecture of chromosomes: Giacomo Cavalli and his colleagues have achieved high-resolution mapping of the different contacts that exist within and between chromosomes. They performed this feat using a new very high-throughput technique improved by the Montpellier team. This major research work should shed new light on the impact of 3D chromosome organization on genome expression and on the onset of diseases such as cancer. It is published in the online version of the journal Cell of 19 January 2012. Continue reading

Learning more about chromosome fragility

© Anne Helmrich

Why are some chromosomal regions particularly susceptible to breakage? Finding the answer to this question is crucial because this fragility is a factor in tumour development. A team from the Institute of Genetics and Molecular & Cellular Biology (CNRS/Inserm/University of Strasbourg) has just solved part of the mystery. Laszlo Tora and his colleagues have discovered that breakage in the longest human genes is caused by a phenomenon that, until now, was thought unlikely to occur in mammalian cells: interference between two key genetic processes, DNA transcription[1] and replication[2]. This research, published in the journalMolecular Cell on 23 December 2011, could eventually lead to novel strategies for fighting tumours.
Continue reading

Record Breaking Explanets Discovered !

Copyright S. Charpinet

An international team led by a CNRS researcher from the Institut de Recherche en Astrophysique et Planétologie (IRAP, CNRS – Université Toulouse III – Paul Sabatier) has discovered the ruins of a planetary system, consisting of the cores of two former giant planets stripped of their gaseous envelopes, orbiting around the remnants of the core of a red giant. These two exoplanets are the smallest, hottest and closest to their parent star ever discovered. This finding, published in the 22 December 2011 issue of the journal Nature. could shed new light on the fate of planetary systems.

Continue reading

French and social media : some trends and challenges for the 2.0 years


© suphakit73 - Fotolia.com

If Facebook is as popular in France as it is in the US, it is not the case of other social media networks and tools such as Twitter, Linkedin, Foursquare and similar applications. Nonetheless, According to the Inria/TNS Sofres survey conducted this year, nearly one French person in two declared they could not do without social networks.

Such interest on its own proves what a success the social web is, although success is not without an increase in private data now present in cyberspace. A thorough grasp of interaction tools and controlling one’s web image are becoming major challenges for tomorrow’s web, both for individuals and companies… as well as a challenge for researchers developing social web management tools. 

To know what the 2012 trends in social media will be, the INRIA interviewed two of the best specialists in France : Frederic Cavazza – Social Media Consultant, and Fabien Gando, Researcher at Inria.

Continue reading

The H1N1 flu vaccine protects both pregnant women and newly-borns

During the 2011-2012 campaign to promote the winter flu vaccination, Odile Launay, Director of the Centre for Clinical Research, Vaccinology, at the Cochin-Pasteur InstituteDirector of vaccinology at the Centre for Clinical Investigation of Cochin Pasteur (Inserm/AP-HP/Institut Pasteur/Université Paris Descartes) published the results of the PREFLUVAC clinical study carried out during the worldwide influenza epidemic of 2009. The researchers studied the immune response of 107 pregnant women after they were injected with a single dose of non-adjuvant H1N1 vaccine. They concluded that the influenza shot boosted the immune response in pregnant women and at the same time protected neuronatal babies via the antibodies that transferred through the placenta.

These results were published in the review Annals of Internal Medicine dated December 6th,.2011. They are available on-line.

Continue reading

French Research Breaktrough : New Technique to See Crystals Like Never Before

An international team of scientists led by the Fresnel Institute (CNRS/Aix-Marseille University/Ecole Centrale de Marseille) and the ESRF (European Synchrotron Radiation Facility) in Grenoble has developed a new technique allowing to observe the nanometer-sized structure of crystalline materials. Using a microscopic X-ray beam to illuminate large areas of a sample, this technique reveals structural details in three dimensions and at high resolution. It could revolutionize research in various disciplines involving the study of complex crystal structures, such as the life sciences and microelectronics. This work is published in the journal Nature Communications dated 29 November 2011.

Continue reading

Plate tectonics may control reversals in the Earth’s magnetic field

The Earth’s magnetic field has reversed many times at an irregular rate throughout its history. Long periods without reversal have been interspersed with eras of frequent reversals. What is the reason for these reversals and their irregularity? Researchers from CNRS and the Institut de Physique du Globe(1) have shed new light on the issue by demonstrating that, over the last 300 million years, reversal frequency has depended on the distribution of tectonic plates on the surface of the globe. This result does not imply that terrestrial plates themselves trigger the switch over of the magnetic field. Instead, it establishes that although the reversal phenomenon takes place, in fine, within the Earth’s liquid core, it is nevertheless sensitive to what happens outside the core and more specifically in the Earth’s mantle. This work is published on 16 October 2011 in Geophysical Research Letters.

The Earth’s magnetic field is produced by the flow of liquid iron within its core, three thousand kilometers below our feet. What made researchers think of a link between plate tectonics and the magnetic field? The discovery that convective liquid iron flows play a role in magnetic reversals: experiments and modeling work carried out over the last five years have in fact shown that a reversal occurs when the movements of molten metal are no longer symmetric with respect to the equatorial plane. This “symmetry breaking” could take place progressively, starting in an area located at the core-mantle boundary (the mantle separates the Earth’s liquid core from its crust), before spreading to the whole core (made of molten iron).

Extending this research, the authors of the article asked themselves whether some trace of initial symmetry breakings behind the geomagnetic reversals that have marked the Earth’s history, could be found in the only records of large-scale geological shifts in our possession, in other words the movements of continents (or plate tectonics). Some 200 million years ago, Pangaea, the name given to the supercontinent that encompassed almost all of the Earth’s land masses, began to break up into a multitude of smaller pieces that have shaped the Earth as we know it today. By assessing the surface area of continents situated in the Northern hemisphere and those in the Southern hemisphere, the researchers were able to calculate a degree of asymmetry (with respect to the equator) in the distribution of the continents during that period.

In conclusion, the degree of asymmetry has varied at the same rhythm as the magnetic reversal rate (number of reversals per million years). The two curves have evolved in parallel to such an extent that they can almost be superimposed. In other words, the further the centre of gravity of the continents moved away from the equator, the faster the rate of reversals (up to eight per million years for a maximum degree of asymmetry).

What does this suggest about the mechanism behind geomagnetic reversals? The scientists envisage two scenarios. In the first, terrestrial plates could be directly responsible for variations in the frequency of reversals: after plunging into the Earth’s crust at subduction zones, the plates could descend until they reach the core, where they could modify the flow of iron. In the second, the movements of the plates may only reflect the mixing of the material taking place in the mantle and particularly at its base. In both cases, the movements of rocks outside the core would cause flow asymmetry in the liquid core and determine reversal frequency.

Read the original article and contacts

Erasing the signs of aging in cells is now a reality

Inserm’s AVENIR “Genomic plasticity and aging” team, directed by Jean-Marc Lemaitre, Inserm researcher at the Functional Genomics Institute (Inserm/CNRS/Université de Montpellier 1 and 2), has recently succeeded in rejuvenating cells from elderly donors (aged over 100). These old cells were reprogrammed in vitro to induced pluripotent stem cells (iPSC) and to rejuvenated and human embryonic stem cells (hESC): cells of all types can again be differentiated after this genuine “rejuvenation” therapy. The results represent significant progress for research into iPSC cells and a further step forwards for regenerative medicine.The results are published in the Genes & Development Journal dated 1 November 2011.

Human embryonic stem cells (hESC) are undifferentiated multiple-function cells. They can divide and form all types of differentiated adult cells in the body (neurones, cardiac cells, skin cells, liver cells, etc., see Figure 1).
Since 2007, a handful of research teams across the world have been capable of reprogramming human adult cells into induced pluripotent cells (iPSC), which have similar characteristics and potential to human embryonic stem cells (hESC). This kind of reprogramming (see Figure 1, opposite, in red) makes it possible to reform all human cell types without the ethical restrictions related to using embryonic stem cells.

Until now, research results demonstrated that senescence (the final stage of cellular aging) was an obstacle blocking the use of this technique for therapeutic applications in elderly patients. Today, Inserm researcher Jean-Marc Lemaitre and his team have overcome this obstacle. The researchers have successfully rejuvenated cells from elderly donors, some over 100 years old, thus demonstrating the reversibility of the cellular aging process.

Figure 1 – © INSERM

To achieve this, they used an adapted strategy that consisted of reprogramming cells using a specific “cocktail” of six genetic factors, while erasing signs of aging. The researchers proved that the iPSC cells thus obtained then had the capacity to reform all types of human cells. They have the physiological characteristics of “young” cells, both from the perspective of their proliferative capacity and their cellular metabolisms.

A cocktail of six genetic factors…

Researchers first multiplied skin cells (fibroblasts) from a 74 year-old donor to obtain the senescence characterized by the end of cellular proliferation. They then completed the in vitro reprogramming of the cells. In this study, Jean-Marc Lemaitre and his team firstly confirmed that this was not possible using the batch of four genetic factors (OCT4, SOX2, C MYC and KLF4) traditionally used. They then added two additional factors (NANOG and LIN28) that made it possible to overcome this barrier (see Figure 2).

Using this new “cocktail” of six factors, the senescent cells, programmed into functional iPSC cells, re-acquired the characteristics of embryonic pluripotent stem cells.

In particular, they recovered their capacity for self-renewal and their former differentiation potential, and do not preserve any traces of previous aging.
To check the “rejuvenated” characteristics of these cells, the researchers tested the reverse process. The rejuvenated iPSC cells were again differentiated to adult cells (see Figure 1) and compared to the original old cells, as well as to those obtained using human embryonic pluripotetent stem cells (hESC).

“Signs of aging were erased and the iPSCs obtained can produce functional cells, of any type, with an increased proliferation capacity and longevity,” explains Jean-Marc Lemaitre who directs the Inserm AVENIR team.

… Tested on cells taken from donors over the age of 100

The results obtained led the research team to test the cocktail on even older cells taken from donors of 92, 94 and 96, and even up to 101 years old. “Our strategy worked on cells taken from donors in their 100s. The age of cells is definitely not a reprogramming barrier.” He concluded. “This research paves the way for the therapeutic use of iPS, insofar as an ideal source of adult cells is provided, which are tolerated by the immune system and can repair organs or tissues in elderly patients.” adds the researcher.
Inserm Transfert filed a patent request for this research.

This article is an extract from the INSERM’s website. All rights reserved.
See the original article. 

How the popularization of the web is tranforming our relationships

This article is an extract of the National Institute Computer Research INRIA website. All rights reserved. Marie Varandat, Oct 7, 2011.

Internet of the New opportunities, new challenges, new risks and new fears are emerging. The Internet of the future, gradually taking shape right now in the research field, has generated numerous debates concerning among other things the protection of privacy.

A debate between Anne-Marie Kermarrec (Senior Research Scientist) and Dominique Cardon (Sociologist).

What are the great milestones of the Internet of the future? What is the major challenge?

Anne-Marie Kermarrec: : Internet usage has changed considerably over the years. Originally reserved for military personnel, it was subsequently used by academic staff. Later, the general public also gained access to it, initially as readers and consumers and today as content producers in their own right, leaving traces and information each time they go online.

Dominique Cardon: This “popularization” of the web is also changing our social behaviour. Back in the pioneering days, the Internet was reserved for a select group of people, most of whom were highly educated. However, with the emergence of social networks in the mid-2000s, all web users now have the possibility to become both readers and participants, thanks to the convergence of communication and publication media technologies. As the pioneers saw it, the web was a completely separate world. Today, it cannot be denied that it has become part of our everyday lives. Our real and virtual lives are increasingly converging.

Anne-Marie Kermarrec: These changes were neither planned nor anticipated. They have left us with some real problems, particularly in terms of data confidentiality and privacy protection. Although the Internet was originally designed as a “web” to limit the risk of the network being destroyed in the event of an attack, the fact nevertheless remains that the data is centralised in the hands of a number of major companies such as Google and Facebook. As this change had not been planned for from a legislative viewpoint, the confidentiality guarantees provided by these companies are relatively weak or even non-existent. Faced with the danger of a “Big Brother” situation emerging, it is now vital to conceive the Internet from something other than a technical angle and to initiate major changes by encouraging the decentralisation of data. The goal must be to bring about the disappearance of “central authorities” possessing complete information about individuals.

Dominique Cardon: The risk is not limited to companies taking control. The centralisation of information can also take place at a state level. We can easily imagine the possibilities for political misbehaviour which arise from such a situation.

Anne-Marie Kermarrec: This problem is central to the work which we are currently undertaking at Inria. Faced with such a danger, we need technology capable of decentralising web functions. Typically, rather than using a search engine on the Internet, the user has a function which, at a given moment, combines several services in order to provide the best possible response.

Moving from an Internet run by companies to an Internet focused on its users.

In other words we will be moving from an Internet run by companies to an Internet focused on its users, in which the services will be combined according to needs, within a precise framework and for a given timeframe. Technically, the task before us is a complex one but is by no means insurmountable. This move to a user-centric Internet must also open up new perspectives regarding the filtering of information – another key challenge for the Internet of the future. Between emails, blogs, websites and chat rooms, today’s web users are drowning under a sea of information. I don’t have any solutions to propose here, but it is clear that we need to find a way of optimising the circulation of information and filtering it to ensure greater relevancy.

Dominique Cardon: Where individuals are concerned, today’s Internet has brought with it some major social repercussions. The dream of democratisation on the part of the pioneers (everyone communicating with everyone) has not become reality. The reason for this is fairly simple. Although the Internet facilitates contact in the virtual world, the principles governing social relationships have remained the same. In other words, in both the virtual world and the real world, people only communicate when they have shared interests. The result is that the Internet has not broken down social and cultural barriers. The groups remain the same. The key players and extroverts of the virtual world are the same as those in the real world whereas the shy and thoughtful types, who nevertheless exist as a real-world group, are disappearing in the virtual world. Other changes likely to have major social consequences are currently underway. Our relationship to paper-based written material is declining while our relationship to writing in general is being transformed. Web users are faced with overabundant information while the numerous economic models generated by the Internet have trouble existing alongside the older models. And these changes are accompanied by the new risk of surveillance and tracking.

Although centralisation brings with it no positive benefits, it must be remembered that interpersonal, decentralised surveillance will also have an effect upon our societies.

I share Anne-Marie Kermarrec’s opinion of the dangers of data centralisation, but I am even more alarmed by the phenomenon of interpersonal surveillance, which has been particularly heightened through the use of social networks. In a more or less consensual manner, web users are publishing enormous amounts of information and are monitoring one another. The boundary between private discussions and public content has not yet been truly established. Collecting data about a given individual is therefore relatively simple and such information can then be used out of context. As an example, a private conversation may be viewed by a recruiter and used to the advantage or detriment of a possible candidate. The relationship between parents and their children may also be affected. To sum up, although centralisation brings nothing positive for us, interpersonal and decentralised surveillance also looks set to turn our society upside down.

Five new genetic susceptibility factors identified for Alzheimer’s disease

A consortium of 108 European laboratories coordinated by a French team (“Public Health and molecular epidemiology of diseases related to aging” UMR 744 Inserm-Lille-Institut Pasteur de Lille) led by Professor Philippe Amouyel (director of the 2010 FAID seminar) and a British team (Centre for Genetic and Genomic Neuropsychiatry, University of Cardiff) have recently identified five new genetic predisposition factors involved in the development of the disease.

The research was conducted by Inserm in close collaboration with the CEA (French national genotyping centre, CEA-IG-CNG), the Fondation Jean Dausset-CEPH and a European consortium of 25 teams.

The discoveries were made thanks to support from the Fondation Plan Alzheimer, which coordinated the research section of the plan, launched in February 2008, to fight Alzheimer’s and other related diseases.

See the full article here.